Title | Signal transduction pathway modeling using sequences of chromatophore images. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Orhanovic, I, Crinon, RJ, Chaplen, FWR, Weisshaar, A |
Journal | IEEE Trans Nanobioscience |
Volume | 6 |
Issue | 3 |
Pagination | 210-8 |
Date Published | 2007 Sep |
ISSN | 1536-1241 |
Keywords | Biosensing Techniques, Cells, Cultured, Chromatophores, Computer Simulation, Image Interpretation, Computer-Assisted, Microscopy, Fluorescence, Microscopy, Video, Models, Biological, Signal Transduction, Subtraction Technique |
Abstract | Extensive research is being done in order to use chromatophore cells as biosensors for various substances. In this paper, a link between the biological aspect of chromatophores and digital image/video processing techniques used for chromatophore characterization is established for this purpose. A model of the Gs--AC--PKA--granule motion-image feature signal transduction pathway is proposed, starting from the concentration of the input ligand and ending in the pigment area extracted from a microscope image. The model extends an existing system biology differential equation based model of the Gs--AC--PKA transduction pathway obtained from the Database of Quantitative Cellular Signaling (DQCS). Examples are presented to demonstrate the effectiveness of the proposed system model. |
Alternate Journal | IEEE Trans Nanobioscience |
PubMed ID | 17926778 |